Enter your email address to subscribe to our most top categories. There was a twofold increase in the risk of endometrial cancer following extended versus standard adjuvant tamoxifen therapy in patients with breast cancer, a meta-analysis found. In this study, our data showed that women with uterine corpus cancer who had a personal history of breast cancer treated with tamoxifen had an increased risk of developing more aggressive UCCs and a lower years free of disease survival. Endometrial cancer Endometrial cancer affects the female reproductive system. In , on 74, breast cancer patients, the use of tamoxifen for more than three years or in patients older than 35 years of age was associated with a significant increased risk for developing endometrial cancer, with odds ratios of 2.
Causes and Risk Factors of Endometrial Cancer
The progesterone protects the uterus. Statistical Methods in Epidemiology. Endometrioid endometrial tumors may be more likely to present with vaginal bleeding and therefore be diagnosed earlier than non-endometerioid tumors, and indeed we saw that these tumor types were more likely to be of a lower FIGO grade at diagnosis. Find articles by Shou-Tung Chen. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Age at diagnosis, tamoxifen use, FIGO stage, and interval between tumors, by morphology of endometrial cancer after breast cancer. Significantly increased medical expenditure on breast cancer failing to bring down its mortality and incidence rate.
Risk Factors and Signs & Symptoms of Endometrial Cancer | Cancer Support Community
Similar results have been published by Narod  and Lasset . Funding for Cancer Training. Age-adjusted rates of endometrial cancer are increasing in countries undergoing transition from low- to high-income economies; although there is no clear, overall trend in high-income countries. Annual Report to the Nation. HRT is used to control the symptoms of menopause, to prevent osteoporosis thinning of the bones , and to reduce the risk of heart disease or stroke. Women who have never been pregnant, those who started menstruation at an early age or who go through menopause at a later age, and women who have had hormone therapy for the treatment of breast cancer all are at an increased risk for endometrial cancer. He added that there are "many factors to consider in choosing endocrine therapy," including menopausal status, risk of breast cancer recurrence, bone health, other comorbid conditions, and tolerance of estrogen deprivation.
Researchers have proposed multiple ways that oral contraceptives may lower the risks of some cancers, including:. Article Sources American Cancer Society. Estrogen can come from a variety of sources including hormonal therapy unopposed estrogen and form obesity fat cells produce estrogen that can stimulate the endometrium. The most common form of endometrial cancer, endometrioid endometrial cancer, is often caused by stimulation of the endometrium by estrogen. Updated April 5, Treatment is discussed in Can endometrial cancer be prevented? In addition, oral contraceptives might increase the risk of cervical cancer by changing the susceptibility of cervical cells to persistent infection with high-risk HPV types the cause of virtually all cervical cancers.